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Marschall S. Runge, MD, PhD, Cam Patterson, MD, and a panel of 251 authoritative contributors-many of them world-renowned clinicians and researchers-have now updated and expanded the much-acclaimed first edition of Principles of Molecular Medicine to provide an integrated survey of the basic principles of internal medicine in the light of recent dramatic discoveries in molecular medicine and new technologies for the diagnosis and treatment of human disease. This second edition contains new sections on genetics, oncology, metabolic diseases, and infectious diseases, in addition to fully revised sections on neurology, cardiology, hematology, nephrology, endocrinology, dermatology, immunology, gastroenterology, pulmonary disease, musculoskeletal medicine, and psychiatry. Here, the reader will discover the latest findings about direct links between genetic mutations and diseases, genomic approaches to a variety of diseases, and stem cell populations that regenerate muscle, heart, and neural cell populations. Other advances elucidated include the roles of bone morphogenetic proteins in pulmonary hypertension, mutations involved in an array of cardiomyopathies, and new understanding of the biology of previously untreatable neurodegenerative diseases, such as Huntington's disease. For this edition, the authors have also focused on producing a tightly written text with more useful figures and tables and reduced references, so that the text is more immediately useful but not overwhelming as a reference book. A CD-ROM edition of the book (ISBN: 1-58829-929-5) is available separately. Comprehensive and state-of-the-art, Principles of Molecular Medicine, Second Edition, offers practicing physicians, researchers, and residents an extraordinary summary of the rapidly emerging molecular mechanisms underlying disease and valuable insights into the nature and direction of future developments.

Medical genetics --- Pathology, Molecular --- Molecular biology --- Genetics, Medical --- Genetic Therapy --- Molecular Biology

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Early clinical trials of the new molecular-based anticancer agents have shown that many are marginal in controlling cancer, but prove to be potent modulators and potentiators of chemotherapy-induced apoptosis when used in combination with classic cytotoxic drugs or radiation. In Combination Cancer Therapy: Modulators and Potentiators, expert physician-scientists and clinicians with first-hand experience in the clinical development of targeted therapies review those combinations that hold the most promise for the future of medical oncology, detailing their optimal sequence, pharmacokinetic interactions, and interaction with downstream cellular signals. The combinations run the gamut of targeted therapies against cell surface receptors (EGF-R and HER2), the cell cycle (the CDKs), signal transduction events (PKC and NF-kB), apoptosis (bcl-2), as well as focused therapies in ovarian cancer, hematologic diseases, and breast cancer. The authors emphasize novel translational approaches that are rapidly moving from the laboratory benchtop to the patient's bedside as a new generation of cancer therapeutics. Cutting-edge and forward-looking, Combination Cancer Therapy: Modulators and Potentiators offers everyone in the fields of cancer drug development and therapy a powerful new understanding of the optimal sequencing and scheduling of new combination drug therapies necessary to maximize the effects for cancer patients today.

Neoplasms --- Drug Therapy, Combination. --- Cancer --- Apoptosis. --- Apoptose --- drug therapy. --- Chemotherapy. --- Treatment. --- Chimiothérapie --- Traitement --- Apoptosis --- Drug Therapy, Combination --- Chemotherapy --- Treatment --- drug therapy --- Cancer -- Chemotherapy. --- Cancer -- Treatment. --- Drug Therapy --- Therapeutics --- Diseases --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Oncology --- Medicine --- Health & Biological Sciences --- Cancer therapy --- Cancer treatment --- Therapy --- Medicine. --- Oncology. --- Medicine & Public Health. --- Tumors --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Medical sciences --- Pathology --- Physicians --- Cell death --- Antineoplastic agents --- Oncology  . --- Cancer - Chemotherapy --- Cancer - Treatment --- Neoplasms - drug therapy

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Clinical interest in the camptothecins continues to expand even though this class of topoisomerase I inhibitors has been studied for almost 50 years, and two early generation members of the family have gained FDA approval. In Camptothecins in Cancer Therapy, leading clinicians and researchers critically review our current understanding of camptothecins, their shortcomings, and the possibilities for improving their clinical performance. The authors discuss new camptothecin analog development, drug delivery issues for optimizing their anticancer activity, and their potential use in a variety of different cancers. Additional chapters describe what is known about the biochemistry, the pharmacology, and the chemistry of the camptothecins, including the mechanism of topoisomerase and how camptothecins poison this enzyme, the use of animal models in defining the anticancer potential of camptothecins, and the question of camptothecin resistance. Authoritative and up-to-date, Camptothecins in Cancer Therapy provides a comprehensive summary of camptothecin research, as well as a much-needed guide to all the latest information on their optimal therapeutic applications.

Camptothecin --- Neoplasms --- Antineoplastic Agents, Phytogenic --- Camptothecin. --- Cancer --- therapeutic use. --- drug therapy. --- analogs & derivatives. --- pharmacology. --- Chemotherapy. --- Chimiothérapie --- Chemotherapy --- therapeutic use --- drug therapy --- analogs and derivatives --- pharmacology --- Cancer -- Chemotherapy. --- Alkaloids --- Diseases --- Therapeutics --- Antineoplastic Agents --- Biological Science Disciplines --- Therapeutic Uses --- Natural Science Disciplines --- Heterocyclic Compounds --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Disciplines and Occupations --- Chemicals and Drugs --- Pharmacologic Actions --- Chemical Actions and Uses --- Pharmacology --- Drug Therapy --- Medicine --- Health & Biological Sciences --- Oncology --- Medicine. --- Oncology. --- Medicine & Public Health. --- Tumors --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Medical sciences --- Pathology --- Physicians --- Antineoplastic agents --- Antiviral agents --- Treatment --- Oncology  . --- Cancer - Chemotherapy --- Camptothecin - therapeutic use --- Neoplasms - drug therapy --- Antineoplastic Agents, Phytogenic - therapeutic use --- Camptothecin - analogs and derivatives --- Camptothecin - pharmacology

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Offers an overview of the knowledge of gastrointestinal immunology and the commensal microbiology of the gut. This book includes chapters dedicated to methodologies used to investigate the microbiota and host: molecular analysis of microbial diversity and gnotobiotic research.

Biomedicine. --- Biomedicine general. --- Immunology. --- Medicine. --- Médecine --- Immunologie --- Bacterial Physiology. --- Gastrointestinal system. --- Gastrointestinal Tract. --- Gastrointestinal system --- Gastrointestinal Tract --- Physiology --- Microbiology --- Bacterial Physiological Phenomena --- Biology --- Biological Science Disciplines --- Digestive System --- Microbiological Phenomena --- Phenomena and Processes --- Natural Science Disciplines --- Anatomy --- Disciplines and Occupations --- Microbiology & Immunology --- Health & Biological Sciences --- Immunology --- Anatomies --- Natural Sciences --- Physical Sciences --- Discipline, Natural Science --- Disciplines, Natural Science --- Natural Science --- Natural Science Discipline --- Physical Science --- Science, Natural --- Science, Physical --- Sciences, Natural --- Sciences, Physical --- Microbial Concepts --- Microbial Phenomena --- Microbiologic Concepts --- Microbiological Phenomenon --- Microbiological Process --- Phenomena, Microbiologic --- Microbiologic Phenomena --- Microbiological Processes --- Concept, Microbial --- Concept, Microbiologic --- Concepts, Microbial --- Concepts, Microbiologic --- Microbial Concept --- Microbiologic Concept --- Phenomena, Microbial --- Phenomena, Microbiological --- Phenomenon, Microbiological --- Process, Microbiological --- Processes, Microbiological --- Ailmentary System --- Alimentary System --- Biologic Sciences --- Biological Science --- Science, Biological --- Sciences, Biological --- Biological Sciences --- Life Sciences --- Biologic Science --- Biological Science Discipline --- Discipline, Biological Science --- Disciplines, Biological Science --- Life Science --- Science Discipline, Biological --- Science Disciplines, Biological --- Science, Biologic --- Science, Life --- Sciences, Biologic --- Sciences, Life --- Bacterial Physiological Concepts --- Bacterial Physiological Phenomenon --- Bacterial Process --- Physiology, Bacterial --- Bacterial Physiology --- Bacterial Processes --- Bacterial Physiological Concept --- Concept, Bacterial Physiological --- Concepts, Bacterial Physiological --- Phenomena, Bacterial Physiological --- Phenomenon, Bacterial Physiological --- Process, Bacterial --- Processes, Bacterial --- Bacteria --- GI Tract --- Digestive Tract --- Digestive Tracts --- GI Tracts --- Gastrointestinal Tracts --- Gastro-intestinal system --- Gastrointestinal tract --- GI tract --- Tract, Gastrointestinal --- Tract, GI --- physiology --- Conformal mapping --- -Functions of complex variables --- -Potential theory (Mathematics) --- -Complex variables --- Conformal representation of surfaces --- Mapping, Conformal --- Transformation, Conformal --- Surfaces, Representation of --- -Analysis--?<061.3> --- Immunobiology --- Life sciences --- Serology --- Clinical sciences --- Medical profession --- Human biology --- Medical sciences --- Pathology --- Physicians --- Functional analysis --- Functions of complex variables --- Potential theory (Mathematics) --- 517 <061.3> --- Geometric function theory --- Mappings (Mathematics) --- Transformations (Mathematics) --- 517 <061.3> Analysis--?<061.3> --- Analysis--?<061.3> --- Congresses --- Complex analysis --- Congresses. --- Health Workforce --- Fonctions d'une variable complexe --- Fonctions de plusieurs variables complexes --- Functions of complex variables - Congresses --- Conformal mapping - Congresses --- Potential theory (Mathematics) - Congresses --- Functional analysis - Congresses --- Theorie du potentiel